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Daptomycin should provide a safe and effective alternative to vancomycin, clindamycin or linezolid for IV treatment of invasive MRSA skin infections. Concerns for vancomycin renal toxicity and clindamycin antibiotic resistance were not present. There was no evidence of daptomycin toxicity in the trial. The Food and Drug Administration is currently reviewing whether to approve daptomycin use in children. MRSA infections are commonly associated with patients in hospitals and nursing homes whose immune systems are weakened, but community-associated MRSA (CA-MRSA) is widespread, readily transmitted at daycare centers, playgrounds and in schools where children have frequent skin-to-skin contact, share toys that have not been cleaned and are more likely to have scrapes, abrasions and bites that offer potential infection entry points. CA-MRSA usually causes skin infections but can lead to more serious consequences, such as pneumonia and infections of bones and joints. Daptomycin is active against MRSA and was approved for use in adults in 2003 for treatment of skin and skin structure infections, and for bloodstream infections three years later. The new study was a prospective, randomized, investigator-blinded study that included more than 250 daptomycin-exposed children, ages 1 to 17, to document safety and efficacy of the antibiotic in treating pediatric skin and skin structure infections. Dosing was based on adult experience, but researchers found that the younger the child, the more quickly their bodies eliminated daptomycin. Thus pediatric doses increased as the age of the research participants decreased. Most news these days is about the declining utility of antibiotics as microbial resistance becomes more widespread and intractable, said Bradley. These findings are encouraging.
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Figures last year showed that almost a third of new teachers who had started jobs in English state schools in 2010 had left within five years. The MPs want measures to tackle problems that make people leave teaching - such as an "unmanageable workload" or a lack of professional development. "The government needs to do more to encourage teachers to stay in the profession by raising the status of teachers, improving the opportunities for good quality training, and by doing all it can to help reduce teacher workload," said Neil Carmichael, who chairs the committee. He said the government could consider "holding fire" on policy changes that added to the pressure on schools. And he suggested schools needed time to support staff development without constantly being "distracted by the demands of the latest Whitehall directive". Malcolm Trobe, leader of the ASCL head teachers' union said: "The crisis in teacher supply has a direct impact on the education that schools are able to provide to their pupils. "It means that important subjects like maths and science have to be covered by teachers who are not specialists in these subjects and that schools have to increasingly rely on supply staff." Dame Alison Peacock, chief executive of the Chartered College of Teaching said: "As well as bringing new talent into our profession, we must stretch every sinew to hang on to that talent and develop it further." Ministers have argued that they have kept teaching as an attractive profession in a competitive jobs market. There have been a series of high-profile advertising campaigns for teaching and there are financial incentives focused on attracting recruits into shortage subjects. Labour's shadow education secretary, Angela Rayner, said the government was "failing to deliver on its most basic of tasks".